Issue 2 On line: 8 April 2026
Working Memory-the Stroop Effect Interactions: A Review of Basic and Clinical ERP Research
MengYu Duan, ZhuoRui Liu, Li Sui
Li Sui, PhD, School of Health Science and Engineering, University of Shanghai for Science and Technology, 516 Jun Gong Road, Shanghai 200093, P. R. China.
Email: lsui@usst.edu.cn
The Stroop task is a classic paradigm for assessing cognitive conflict and control, and the resulting Stroop effect has been widely used as an index of interference and control efficiency. Working memory (WM) plays a pivotal regulatory role in higher-order cognition, including attentional modulation, conflict inhibition, goal maintenance, and executive functioning. Within the Stroop paradigm, performance is shaped not only by externally induced stimulus conflict but also by internally generated interference arising from information maintained in WM, thereby increasing task complexity. The interaction between WM and the Stroop effect is a central focus in basic neuroscience and psychology. Clinical evidence indicates that individuals with various neurological and psychiatric disorders exhibit altered performance on tasks combining WM and Stroop demands, particularly in key event-related potential (ERP) components such as the N450 and P3. Dynamic alterations in these components have emerged as informative biomarkers for delineating pathological mechanisms of impaired cognitive resource allocation, conflict monitoring, and executive control in neuropsychiatric populations. Addressing the current lack of comprehensive and critical synthesis, this article presents a narrative review evaluating neural mechanisms, characteristic ERP signatures, and recent advances in applying WM–Stroop paradigms across diverse clinical groups. Beyond summarizing extant findings, the review develops a stage-specific account of how WM load and WM contents modulate conflict-related ERP components across different populations, and offers a critical appraisal of major methodological limitations, including paradigm heterogeneity, sample variability, and constraints on generalizability. The article concludes by outlining future directions and emerging trends to inform theory development and guide empirical research.
Keywords: event-related potentials, working memory, Stroop effect, N450, P3